Products / Retinol 0.25% Treatment Cream
Retinol 0.25% Treatment Cream
Retinol 0.25% Treatment Cream
Retinol 0.25% Treatment Cream
Retinol 0.25% Treatment Cream
Retinol 0.25% Treatment Cream
Retinol 0.25% Treatment Cream

Retinol 0.25% Treatment Cream

48 Reviews

Gently clears acne, smooths skin, softens fine lines, best for beginners

ADD TO CART

Benefits

✓ High-strength 0.25% Retinol concentration
✓ Improves the skin's texture for a more youthful-looking skin
✓ Reduces skin blemishes
✓ Targets fine wrinkles and uneven skin tone
✓ Formulated for sensitive, acne-prone skin
✓ Vegan and cruelty-free
✓ Paraben, sulfate, and silicone-free
✓ Dermatologist designed, tested, and approved

Overview

This unique Retinol treatment cream combines the magic of high-strength 0.25% Retinol and 2.0% Niacinamide. Pure Retinol works to unclog pores and prevent acne blemishes and fine wrinkles without over-drying the skin. Niacinamide (vitamin B3), a powerful anti-inflammatory ingredient, hydrates the skin, improves the skin's texture, and helps fade post-acne dark spots.

Size: 0.5 oz | 15 ml

Key Ingredients

Pure Retinol 0.25%
A powerful Retinoid that is converted in the skin to active Retinoic acid. It increases the skin's cell turnover, unclogs pores, and helps reduce the appearance of blemishes, fine lines, and wrinkles.

Niacinamide 2.0%
A form of vitamin B3. It enhances the skin's protective barrier and helps reduce the appearance of blemishes, large pores, and hyperpigmentation.

Treatment Boosters

🌱 Tea tree oil
Potent antimicrobial and antifungal with proven medical-grade efficacy for acne.

🌿 Aloe Vera leaf extract
A powerful antioxidant that hydrates and reduces redness and irritation.

🌼 Chamomile Extract
An effective antioxidant, anti-bacterial and anti-fungal with potent skin-soothing properties.

🌸 Calendula Officinalis Extract
Highly effective anti-inflammatory and antibacterial compound used by dermatologists to soothe irritated skin.

🌻 Sunflower extract
A powerful ingredient that helps neutralize free radicals and exhibits strong anti-glycation properties.

🎋 Licorice extract
A potent antioxidant that prevents and helps fade brown spots.

How to Use

Apply your retinol cream at night on clean, dry skin. In the beginning, apply it twice per week, and gradually increase the application frequency. Apply a pea-sized amount to your finger and touch the four areas of your face: forehead, chin, and the two cheeks, avoiding contact with eyes, eyelids, and lips. Always apply sunscreen when outdoors.

Retinol products are not recommended for use by pregnant or nursing mothers.

Instructions for Women

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Instructions for Men

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Full Ingredient List

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Aqua (Deionized Water), Aloe Barbadensis Leaf (Aloe Vera Gel) Juice, Isopropyl Myristate, Glyceryl Stearate, Niacinamide, Stearic Acid, Helianthus annuus (Sunflower) Oil, Polyacrylamide, C13-14 Isoparaffin, Laureth-7, Retinol (Vitamin A), Allantoin, Melaleuca Alternifolia (Tea Tree) Oil, Chamomilla Recutita (Chamomile) Extract, Glycyrrhiza Glabra (Licorice) Extract, Thymus Vulgaris (Thyme) Extract, Calendula Officinalis Extract, Polysorbate 20, Phenoxyethanol, Ethyhexyl glycerin.

 

 

 

 

 

 

 

Your questions, answered

What is MDacne Retinol 0.25% Treatment Cream and how does it work?

MDacne Retinol 0.25% Treatment Cream is a cosmetic night cream with 0.25% pure retinol and 2% niacinamide. Retinol converts to retinoic acid in the skin and speeds cell turnover, which helps keep pores clear and smooths texture. Niacinamide calms redness and helps fade dark spots.

Is MDacne Retinol 0.25% Treatment Cream better than other retinol products?

MDacne Retinol 0.25% Treatment Cream uses pure retinol, the form your skin converts directly to retinoic acid, paired with 2% niacinamide to offset dryness. Tea tree oil, aloe vera, chamomile and calendula soothe the skin, and the formula is vegan and free of parabens, sulfates and silicones.

MDacne Retinol 0.25% or 0.5% — which strength should you start with?

MDacne Retinol 0.25% Treatment Cream is best for anyone new to retinol or with sensitive skin, since it is the beginner strength. Move to MDacne Retinol 0.5% Treatment Cream, which is twice as potent and paired with 4% niacinamide, once you tolerate nightly use comfortably.

How long does MDacne Retinol 0.25% Treatment Cream take to show results?

MDacne Retinol 0.25% Treatment Cream usually improves texture and tone by week six to eight. Fewer clogged pores and smoother skin build over three months, since you start at twice weekly. Retinol results are cumulative, so consistency matters more than frequency.

How do you use MDacne Retinol 0.25% Treatment Cream at night?

MDacne Retinol 0.25% Treatment Cream goes on at night to clean, dry skin, twice a week at first, then more often as your skin tolerates it. Use a pea-sized amount on forehead, chin and both cheeks, avoiding eyes and lips. Always wear sunscreen outdoors.

Does MDacne Retinol 0.25% Treatment Cream cause purging, and how long?

MDacne Retinol 0.25% Treatment Cream can cause more breakouts in the first two to six weeks, as retinol pushes existing clogs to the surface. Keep to twice weekly, moisturize, and let it settle rather than stopping. Message our team if breakouts worsen past six weeks.

Who should not use MDacne Retinol 0.25% Treatment Cream?

MDacne Retinol 0.25% Treatment Cream is not recommended if you are pregnant or nursing. Mild dryness, redness or flaking is common early on, so reduce frequency and use a moisturizer. Retinol increases sun sensitivity, which is why daily sunscreen is not optional with this cream.

4.5

Based on 48 Reviews
Lauren Verified Customer
Trust the Process MDacne Is Working for Me
I started using MDacne on December 19th, and I began the routine the same day my package arrived. The first thing I tried was the pore patch for my nose (I used it on my cheek area), and I was honestly shocked by how much it pulled out dead skin, dirt, oil, and who knows what else. The next day, my pores already looked smaller and noticeably smoother. After about a week, I started experiencing dryness and peeling. I reached out to Sarah G. from MDacne, and she explained that dryness, tightness, and peeling are completely normal with effective acne treatments. She recommended using an under‑eye cream as a barrier before applying the medicated products, which helped. I also didn’t experience any purging, which was a relief. Overall, my skin is definitely smoother and brighter. My dark marks have started to fade, although the upper cheek area where I had the most clogged pores hasn’t fully lightened yet. I may look into adding a retinol or a dark spot treatment if MDacne recommends it. This isn’t an overnight miracle, but I can genuinely say my skin has improved. You really do have to trust the process. I can honestly say the free trial is worth a shot.
Magan Landry Conner Verified Customer
Customer service is great
Customer service is great. Been using the face wash for 2 months and love the results. Too soon to tell with retinol will update
Nadia “Nads” Lanique Verified Customer
It’s been only a few weeks since I…
It’s been only a few weeks since I started using the customized kit, but I do very much enjoy it. It stopped my large breakouts and I like the balance of different topical treatments between the wash and moisturizers. I will say, it is drying as it suggests but balancing out the right routine and frequency for you will help. 4/5 rating because I still need more time to see how I enjoy the product long term and I also feel like it doesn’t help with my hyperpigmentation, and in some cases it leaves marks from my acne bumps as apart of the process. In this, I can tell it’s working but it’s still something to navigate. I suggest switching between the benzoyl peroxide & retinol at night or including a toning brightener of some sorts to help (again caution to drying and irritation). Always add in products slowly and sparingly to be safe!
Nicole Alston Verified Customer
I am liking my products
I am liking my products. I recently received my order and have a retinol cream as well now that I'm excited about in addition to my acne cream and face wash and moisturizer. My skin is way less oily and much smoother. Im looking forward to clear skin. I have been having some purging.
ALVINE MAHFRI Verified Customer
Words alone can not express how this…
Words alone can not express how this retinol from MD Acne has improved my skin it’s so so effective especially when you are consistent I will definitely recommend 💯 💯💯💯

Related Products