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Best OTC Azelaic Acid Product for Acne

What is Azelaic Acid?

Azelaic acid is a versatile skincare ingredient widely used in topical treatments for acne. Applied once or twice daily to affected areas, it works by reducing keratin production, a protein that can block pores, and has antimicrobial properties to fight acne-causing bacteria. Additionally, azelaic acid’s anti-inflammatory effects help reduce redness and swelling associated with acne, making it effective for various skin concerns.

Why is Azelaic Acid a Skincare All-Star?

Azelaic acid offers multiple benefits beyond treating acne, which is why it's so highly valued in skincare. Besides its anti-acne properties, azelaic acid helps brighten the skin and improve overall tone by addressing hyperpigmentation, including post-inflammatory hyperpigmentation (PIH) and melasma. Its anti-inflammatory effects can also help soothe conditions like rosacea, while its antioxidant properties protect against free radicals and environmental stressors. These combined effects make azelaic acid a powerful, multifaceted skincare ingredient.

Does Azelaic Acid Cause Purging?

Unlike some acne treatments, azelaic acid does not generally cause purging. Instead, it helps regulate cell turnover and fight acne-causing bacteria, gradually reducing breakouts. If you experience worsening acne or cystic breakouts, it’s best to consult a dermatologist to determine if azelaic acid is right for you.

How Does Azelaic Acid Improve Skin?

Azelaic acid supports skin health in several ways:

  • Normalizing Keratinization: It reduces clogged pores, preventing blackheads and whiteheads.
  • Antimicrobial Action: It targets acne-related bacteria, reducing breakouts.
  • Anti-Inflammatory Effects: It calms redness and irritation, beneficial for both acne and rosacea.
  • Brightening Skin Tone: It can reduce melanin production, making it helpful for fading dark spots and evening skin tone.

Is Azelaic Acid Effective?

Azelaic acid is an effective treatment for acne, with clinical studies showing significant reductions in both inflammatory and non-inflammatory acne. In some cases, its effectiveness matches that of benzoyl peroxide and topical antibiotics. However, individual results may vary, and improvements typically appear within a few weeks to months of consistent use.

Can Azelaic Acid Help with Scars?

Azelaic acid is effective in fading PIH and dark spots left by acne but may not fully address deeper acne scars, like icepick or boxcar scars. For more severe scarring, treatments like laser therapy, chemical peels, or microneedling might be needed in addition to azelaic acid.

Is it Safe to Leave Azelaic Acid on Overnight?

Generally, yes. Azelaic acid can be used overnight, but it’s wise to start with a lower concentration to assess skin tolerance. If you experience irritation, consider reducing application time or consulting a dermatologist.

What is the Best OTC Azelaic Acid Product for Acne?

MDacne's excellent over-the-counter option is the Sulfur + Azelaic Treatment Cream, designed for acne- and rosacea-prone skin. This cream combines the benefits of 3% pure sulfur with azelaic acid and niacinamide, helping to reduce redness, blemishes, and dark spots without causing over-dryness. The addition of natural ingredients like green tea, cucumber, chamomile, vitamin E, and licorice extracts provides extra support to even skin tone, reduce sebum production, and enhance skin’s healing process.

Application Tips: Apply a pea-sized amount to the forehead, chin, and cheeks, avoiding the eyes, eyelids, and lips. MDacne’s formula is vegan, cruelty-free, and free of parabens, sulfates, and silicones, making it a well-rounded choice for sensitive, acne-prone skin.

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Sulfur for acne, fungal acne, and rosacea

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Sulfur + Azelaic Treatment Cream

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